Post-Doc, Engineering Science
St. Cross College
Thesis Title: Epidermal powdered DNA Immunization
About
The skin is an ideal site for the delivery of vaccines for its relative accessibility and the presence of immunologically sensitive cells. Over the years, the University of Oxford has engineered ballistic devices (gene guns) to deliver vaccines in micro-particles powdered form to skin to bring about a therapeutic effect. Ballistic vaccinations have been very successful over the years in a number of pre-clinical models of disease but in order for this technology to become a routine method in the clinic it needs to be better understood in terms of particle delivery mechanics, skin biology and the elicited systemic immune responses observed. The aim of this study is to better understand biological responses in skin upon micro-particle impact so that local tissue biology can be linked with observed systemic responses to draw meaningful conclusions.
Contact Information
http://www.eng.ox.ac.uk/chemeng/membrane/paul.htm
St. Cross College
St. Giles
Oxford, OX1 3LZ
+44(0) 01865-273177
+44(0) 7881584782
