Graduate Student, Department of Computer Science
Keble College
Thesis Title: Towards In Silico Drug Discovery in the Colorectal Crypt
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Prof. David Gavaghan
Dr. James Osborne Prof. Helen Byrne |
About
My research primarily involves development of cell-based models for colorectal cancer (CRC), working at the subcellular and cellular scales of interest.
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* Development of dynamical systems models for several key biochemical pathways implicated in CRC, and their impact upon mitotic mechanisms via the cell cycle;
* Specific emphasis upon crosstalk between the Notch and Wnt pathways and the effect of such interaction on local and global cell behaviour within the colorectal epithelium;
* Development of a multiscale framework coupling cellular behaviour with the subcellular considerations mentioned above and subsequent application of this framework to in silico translation experiments, exploring the impact of tissue geometry upon the expression of subcellular biochemistry;
* Application of these techniques to drug discovery problems, for example studying drug synergies within the intestinal crypt.
Previous work in computational biology has included:
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* FLUID DYNAMICS OF THE EYE (work with Dr. Andrew Hazel, Manchester 2008): Finite element methods for modelling the flow of liquefied vitreous humour within the human eye;
* CELLULAR POTTS MODELLING OF THE COLORECTAL CRYPT (work with Prof David Gavaghan and Dr. James Osborne, Oxford 2009): Application of the CPM to modelling the colorectal crypt, examining its suitability for representing the tissue;
* PERINEURAL TUMOUR INVASION (work with Prof. Philip Maini and Dr. Alex Fletcher, Oxford 2009): Examination of discrete versus continuum approaches for modelling migration of tumour cells towards the perineural sheath in cancers of the head and neck.
In addition to my doctoral research, I am also employed as a Research Assistant for the Networks cluster of the Keble Advanced Studies Centre.
Contact Information
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